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The Benefits Of Being ill

The Benefits Of Being ill

Why do some diseases still exist after all those years of evolution?

factor V Leiden, disease, ill, evoluition, adantage, malaria, sickle-cellA lot has changed in the human body since our ancestors walked around on bare feet. We have less hair, we got bigger and we live longer, for example. But we’re still being haunted by some very stubborn diseases that survived the evolution. How is that possible?

It’s of course a difficult question with many answers and a lot of them are still unknown . But with some specific health problems we are starting to understand what happened to keep them alive. A new example is Factor V Leiden, a blood mutation present in around 5 percent of Caucasians, that is associated with thrombosis and pregnancy complications, such as miscarriage.

The mutation started in just one individual 34.000 years ago, relatively shortly after the Caucasians split apart from other human subpopulations. Despite its hampering effect on the carrier’s health, Factor V Leiden is still around.

Maybe that’s partly because the mutation is helping women to get pregnant, Drs Thijs van Mens just wrote in the journal Thrombosis and Haemostasis.  “Studies suggest that women with Factor V Leiden get pregnant significantly faster in some specific groups than those that don’t have the mutation and that women with Factor V Leiden are more likely to get a successful IVF.”

There are other examples of diseases with evolutionairy benefits. Van Mens mentions sickle-cell disease that’s present in regions where malaria is common. The homozygous variant can cause bloodclots and other healthproblems. People with the heterozygous variant, on the other hand, experience few health problems and enjoy a big advantage: both variants make their carriers more resistant to Malaria.

If you like to know more about the mystery of evolution: last week featured a blog suggesting that evolution doesn’t always need competition.

Photo: Flickr, MestreechCity
Source: van Mens, T., Levi, M., & Middeldorp, S. (2013). Evolution of Factor V Leiden Thrombosis and Haemostasis, 110 (1) DOI: 10.1160/TH13-02-0115

van Mens TE, Kaandorp SP, Goddijn M, et al. Factor V Leiden and time to pregnancy; an evolutionary advantage? J Thromb Haemost 2011;9:O-TH-093.

factor v leiden pregnancy, factor v leiden heterozygote, factor v leiden deficiency

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