728 x 90
728 x 90

HIV: The Basics

HIV: The Basics

A concise explanation of HIV/AIDS

HIV (Human Immunodeficiency Virus) is a retrovirus that can be transmitted between people by unsafe sexual contact, if at least one person is infected with HIV. In infected humans, the HIV-virus enters cells that express the cell surface protein CD4 and co-receptors CCR5 and/or CXCR4. When this virus enters the cell, it converts the genetic information of HIV (or RNA) into DNA with reverse transcriptase. The DNA is then incorporated in the host cell’s chromosome and can subsequently be replicated and used to make viral proteins (see figure below). When there are enough copies of the virus, the host cell bursts open releasing the viruses to find new host cells and the host cell dies.

hiv, aids, cells, autoimmune, CXCR4, viral infection, CD4, CD5

The most common victim of HIV is the CD4 T cell and the number of these cells decline during HIV infection. Because CD4 T cells are essential for the functioning of the immune system, this decline is the main reason for the weakened immune system of the HIV-patients. As a consequence, late-stage HIV-patients are susceptible to infections that are harmless in healthy humans. The most advanced stages of HIV-infection are generally known as AIDS (Acquired Immunodeficiency Syndrome).

Symptoms

The first symptoms occur shortly after the HIV-infection. Patients usually display symptoms like a sore throat, fever and a blotchy red rash. These early symptoms last up to three weeks and are commonly diagnosed as flu or a mild viral infection. After that, the HIV-infection can stay without symptoms for many years before the patient’s immune system will start to get significantly weaker. Common symptoms of a more advanced HIV-infection and AIDS are swollen lymph nodes, recurring herpes and weight loss.

Prevention and treatment

To prevent HIV infection from entering the AIDS stage, quick diagnosis and adequate treatment is needed. New diagnostic tools are able to detect HIV a month after infection, even before the patient expresses HIV-specific symptoms. If an infection is picked up on early, the doctor will regularly check the CD4 T cell count in the blood. One of the common treatments is the so-called antiretroviral therapy (ART). This therapy prevents common symptoms of HIV by slowing down the replication of the HIV virus.

Read the interview with Prof. Mancini about improving HIV treatment with computer simulation.

Leave a Comment

Your email address will not be published. Required fields are marked with *

Cancel reply

3 Comments

  • calif
    March 1, 2018, 14:41

    Hello everyone out there i have a very important story to share with you about my pass live that makes me a very happy man today to come hare start talking about it, I am Calif from USA, am very happy to share this great news about a great and powerful DR frank who cured me of blood cancer that almost take my life. I suffered this illness for 5 years I could not find a cure i do nothing but cry
    day by day on till one day I was working on something online when I saw a blog where a woman was showing a powerful DR performance online how he help her with the cure of HIV i have no choice at that time to dough anything but believe everything that come my way to i have to take he contact and contacted him for helped she also mentioned that this same Man can also cure any Cain of disease with herbal medicines, without wasting more time I contacted him in his email
    (drfrankhealinghome104@gmail.com) and explained all my problems to him. He told me not to worry about what is already done that he we help me at first i see it as joke, He said that is going to prepare an herbal medicine and that He would send it to me. the Dr said the use of herbal medicine according to their requirements can do a lot for any seek one out a lot, and I started using it before I knew I felt changes in me, two weeks later, I went to the hospital for a medical checkup and to my surprise I was completely cured of the blood cancer. I am very happy smile that I am free from disease, all thanks and gratitude to God and DR frank. If you are outside suffering from herpes, HIV, cancer, diabetes, low spam cam need kids,marriage problems, asthma, brain fog or any kind of illness, quickly contact this powerful man by email (drfrankhealinghome104@gmail.com) and whats app number +2348025760554

    REPLY
  • Johnson Kings@Anonymous
    March 2, 2018, 23:19

    Hey, I’m Gloria Mark from USA, I never imagined herbal remedy could treat DEPRESSION until i read and meet an African herbalist online named Dr White. I read a lot of people commending him of being able to cure HIV, HERPES and other deadly diseases. I wrote him because my nice was suffering from what the physicians called acute and severe depression. After taking her to several psychiatrists, she had several sections of psychotherapy and several drugs administered including antidepressants but she never recovered. With little conviction but determination to end her suffering I wrote Dr White but a week intake of Dr White’s herbal remedy did the magic and today she’s perfectly ok and back to work, should you have or know anybody with DEPRESSION or HIV please contact this great healer on drwhitethehivhealer@gmail.com or watsapp +234(0)9091844595. I bear witness you will not regret doing so because I take it on me to tell the world about this.

    You may reach me on: markgloria80@gmail.com

    REPLY
  • Johnson Kings@Johnson Kings
    March 2, 2018, 23:22

    hey guys, the above is a testimony from another beneficiary of doc White’s miracle. dont chain your self to Aids

    REPLY